Besides its importance for veterinary medicine, it is also a valuable spontaneous model for non-infectious autoimmune-mediated recurrent pan-uveitis in humans, due to strong clinical and immunopathological similarities such as occurrence of shared autoantigens (cellular retinaldehyde-binding protein (CRALBP), interphotoreceptor retinoid-binding protein (IRBP), soluble antigen (S-Ag)) [12,13,14,15,16] and spontaneous onset of disease with remitting-relapsing character and unsolved etiology [17,18]. Here, RBP3 is linked to uveitis.