In contrast, IL-2-stimulation results in mTORC1Strong or Yang signaling, leading to activation of the transcriptional T-bet (Yang) and metabolic HIF-1α (Yang) pathways and cell differentiation into IL-2/TE cells that are proliferative, effective at killing tumor or infected cells, and utilize glycolysis for energy production (Figure 6A). Here, IL2 is linked to neoplasm.