Another study demonstrated that G9a, a histone methyltransferase responsible for histone H3 lysine 9 (H3K9) mono- and demethylation, is required for EMT-induced DNA methylation at the E-cadherin (CDH1) promoter in three model cell lines, and in Claudin-low breast cancer CLBC [100]. The gene discussed is CDH1; the disease is breast cancer.