A recent study shows that LEAP-2 levels decrease significantly, and the Ghrelin/LEAP-2 ratio increases significantly in children with obesity, suggesting that this condition could favor the orexigenic, diabetogenic and lipogenic effects of ghrelin, similar to the physiological conditions that occur during pregnancy, as reported in the present study [27]. This evidence concerns the gene GHRL and obesity due to melanocortin 4 receptor deficiency.