In the present study, a progressive increase in levels of LOX, LOXL1, and LOXL3 expression was observed for LGG-IDHmut, LGG-IDHwt, and GBM in the TCGA glioma RNAseq dataset, suggesting their role in determining ECM composition and stiffness enhancement in these phenotypes. This evidence concerns the gene LOXL1 and central nervous system cancer.