Interestingly, there was a progressive increase in CTNNB1, which codes for β-catenin, according to astrocytoma malignancy grade, and its expression correlated significantly with LOXL1 and LOXL3 expression in both LGG-IDHmut and LGG-IDHwt. The gene discussed is LOXL1; the disease is astrocytoma (excluding glioblastoma).