In the present study, a progressive increase in levels of LOX, LOXL1, and LOXL3 expression was observed for LGG-IDHmut, LGG-IDHwt, and GBM in the TCGA glioma RNAseq dataset, suggesting their role in determining ECM composition and stiffness enhancement in these phenotypes. The gene discussed is LOX; the disease is glioma.