Figure 7 summarizes our findings. More specifically, the LOXL1 correlation net was detected in less malignant astrocytomas. Connectivity with LOXL3 was prominent among more aggressive LGG-IDHwt, and strong connectivity with LOX was detected in GBM, demonstrating the complexity of ECM components involved in astrocytoma progression. The gene discussed is LOXL1; the disease is astrocytoma (excluding glioblastoma).