TP53 and leukemia: Apoptosis was also observed in other different cell types where the antiproliferative effects of DADS were investigated such as p53-wild type H460 and p53-null type H1299 non-small-cell lung cancer cells [63], in human glioblastoma cells [68], human leukemia cells [72], human esophageal carcinoma cells [84,85] or primary effusion lymphoma cells [87].