IL6 and Alzheimer disease: Evidence from transgenic animal models of AD (APPsw/Tg2576 mice) has proven the significant impact of long-term (15 months) diet supplementation with pomegranate fruit (4% w/w) on the level of the main pro-inflammatory cytokines, namely IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-1β, and TNF-α, with interesting anti-amyloidogenic effects [3] (Figure 1B).