Neurodegeneration in these disorders affects neuronal death, which has been linked to the presence of toxic protein deposits in the central nervous system (CNS), including Aβ and Tau for AD, α-synuclein for PD, and superoxide dismutase 1 (SOD1) and TAR-DNA-binding protein (TDP-43) for ALS [10,11]. Here, TARDBP is linked to Alzheimer disease.