PSMB9 and Hashimoto thyroiditis: We found that genes in the regulatory network were also enriched in the proteasome pathway and the processes of proteasomal protein catabolic process, and proteasome-mediated ubiquitin-dependent protein catabolic process, which can explain a previous finding that the immune proteasome LMP2 can be used as a new target for the treatment of autoimmune hypothyroidism [40].