AKT1 and Alzheimer disease: Since we also detected upregulation of the aforementioned regulators along with reduced phosphorylation of the NF-κB p65 subunit in the retina of APP/PS1 mice with microglial miR-155 inhibition, we postulate that the anti-inflammatory effect of microglial miR-155cKO in the AD retina is partially due to activation of PI3K-Akt signaling cascades and decreased MGnD populations.