APOE and Alzheimer disease: A recent RNAseq analysis identified a distinct neurodegeneration and disease-associated microglial phenotype (MGnD/DAM) that is regulated via the triggering receptor expressed on the myeloid cells 2-apolipoprotein E (TREM2-APOE) pathway and is closely associated with cerebral amyloid β-protein (Aβ) plaques, a pathological hallmark of AD [43, 47].