In this study, extracellular K+ efflux inhibited the NLRP3 inflammasome activity induced by BC in a dose-dependent manner, and effectively inhibited the expressions of IL-1β and IL-18 and cell death at 50 mmol/L K+ efflux (Fig. 4A–C, P < 0.05). This evidence concerns the gene NLRP3 and breast cancer.