AP-2β can target multiple features of obesity and T2D centrally and peripherally by modulating key-obesity linked genes such as IRS-1, GLUT4, adipocytokines related genes, as well as catecholaminergic and serotonergic genes involved in reward, consummatory behaviour and insulin resistance (Table 3). This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.