For example, while TFAP2Β/AP-2β overexpression has already been suggested as a favourable prognostic marker in neuroblastoma[33, 210], it might further be considered as a biomarker for other MNDs where TFAP2Β/AP-2β overexpression is implicated, such as alcoholism, obesity, T2D and aggression. This evidence concerns the gene TFAP2A and obesity due to melanocortin 4 receptor deficiency.