While genetic variants of TFAP2Β have been suggested to play a role in resilience to AD [189], increased AP-2β has been shown to bestow a neuroprotective effect in AD due to the AP-2β-enhancing effect on the expression of apolipoprotein E (apoE), an important protective protein in AD pathogenesis [32, 190]. The gene discussed is TFAP2B; the disease is Alzheimer disease.