4-1BB, also called CD137 or tumor necrosis factor receptor superfamily member 9 (TNFRSF9), is a costimulatory molecule expressed functionally on the surface of various types of leukocytes, such as T cells, natural killer (NK) cells and subsets of dendritic cells, and can be activated by its ligand 4-1BBL or activating anti-4-1BB antibodies to enhance tumor rejection; thus, it is regarded as a potential target for cancer immunotherapy [5–7]. The gene discussed is TNFRSF9; the disease is cancer.