EGFR and head and neck squamous cell carcinoma: mRNA coefficients and the median threshold of the prognostic model trained in the TCGA cohort were transferred to validation cohorts (MDACC-HNSCC, n = 74; FHCRC, n = 97; Supplementary Table 2) and confirmed the correlation of the EGFR-mediated EMT-based risk score with poor OS (Fig. 4H; MDACC: HR 3.92, 95% CI: 1.9–8.11, p-value = 6.13e-05; FHCRC: HR 3.32, 95% CI: 1.73–6.38, p-value = 8.89e-05).