All components of this receptor-ligand complex, i.e. ITGA6, ITGB4, LAMA3, LAMB3, and LAMC2, were up-regulated in HNSCC mRNA expression data (Supplementary Figs. 4– 8), and significantly correlated to ITGB4 in bulk tumor and in malignant single cells mRNA expression data (Supplementary Fig. 3). Here, LAMC2 is linked to head and neck squamous cell carcinoma.