Normal mucosa (n = 34), and HNSCC (n = 238) and matched pairs of normal mucosa and HNSCC (n = 34) from the TCGA cohort were assessed for the expression of integrin alpha 6 (ITGA6) and laminin 5 genes LAMA3, LAMB3, and LAMC2. This evidence concerns the gene LAMB3 and head and neck squamous cell carcinoma.