Cervical cancer often harbors activating somatic mutations, including E74 Like ETS Transcription Factor 3 (ELF3) and Core-Binding Factor Subunit Beta (CBFB) genes, and inactivating somatic mutations in the F-Box And WD Repeat Domain Containing 7 (FBXW7), Major Histocompatibility Complex, Class I, B (HLA-B) and E1A Binding Protein P300 (EP300) genes, which may drive oncogenic transformation and chemotherapy resistance of cervical cancer [10]. The gene discussed is EP300; the disease is cervical cancer.