In this retrospective observational cohort study of patients with a first diagnosis of essential hypertension, we found that SBP, DBP, hs-CRP, SBP drop rate, DBP drop rate, 24-h standard deviation of SBP, 24-h standard deviation of DBP, 24-h SBP coefficient of variation, and 24-h DBP coefficient of variation were associated with new-onset essential hypertension in patients admitted in winter. This evidence concerns the gene CRP and essential hypertension.