TP53 and Familial prostate cancer: The 17p13.1 variant, rs78378222, (OR = 4.47, 95% CI = 2.75–7.27, P = 1.56 × 10−9) is a 3′ UTR variant of the commonly mutated tumor suppressor gene TP53 that increases susceptibility to different types of cancer (e.g., skin basal cell carcinoma, prostate cancer, glioma, and lymphocytic leukemia)34–37.