TET2 and myeloproliferative neoplasm: At 4q24, rs1548483, located near TET2, a putative tumor suppressor gene and common somatic driver mutation in clonal hematopoiesis28,29, was significant (OR = 2.27, 95% CI = 1.71-3.01, P = 1.42 × 10−8); notably, this variant is in high LD with the previously identified MPN variant rs62329718 (R2EUR = 0.94, D′EUR = 1.00)20.