The 17p13.1 variant, rs78378222, (OR = 4.47, 95% CI = 2.75–7.27, P = 1.56 × 10−9) is a 3′ UTR variant of the commonly mutated tumor suppressor gene TP53 that increases susceptibility to different types of cancer (e.g., skin basal cell carcinoma, prostate cancer, glioma, and lymphocytic leukemia)34–37. Here, TP53 is linked to skin basal cell carcinoma.