The 17p13.1 variant, rs78378222, (OR = 4.47, 95% CI = 2.75–7.27, P = 1.56 × 10−9) is a 3′ UTR variant of the commonly mutated tumor suppressor gene TP53 that increases susceptibility to different types of cancer (e.g., skin basal cell carcinoma, prostate cancer, glioma, and lymphocytic leukemia)34–37. The gene discussed is TP53; the disease is central nervous system cancer.