Notably, at endpoint, histoscores for p53 staining were highest for the heaviest tumours (Fig. 2b), with Trp53(R245W/R245W) (7 = 4 + 3) surpassing Trp53(R172H/R172H) (5 = 2.25 + 2.75); (Fig. 3b). Here, TP53 is linked to neoplasm.