Explicitly, the proportion of CD8+ cells increased over time for Trp53(R172H/R172H) tumours at the expense of CD4+ cells; for Trp53(R245W/R245W), the relative proportion of B cells increased at the expense of the CD8+ cell populations; for Trp53(−/−) tumours while the denisty of CD4+ cell populations was similar between timepoints, the proportion increased at endpoint, due to concomitant lowering of the relative fraction of CD8+ cells. This evidence concerns the gene CD8A and neoplasm.