CCL5 and neoplasm: In addition, at 12 weeks in Trp53(R172H/R172H) and Trp53(R245W/R245W) tumours, the Tumour Inflammation Signature analyses (described in [38]; Supplementary Fig. 5a–c) identified elevated expression of CCL5 (C-C chemokine ligand 5; Supplementary Fig. 5b), which is produced by tumour associated macrophages.