TGFB1 and central nervous system cancer: Notably, relative to the other genotypes at the same 12 week time point, in Trp53(R245W/R245W) tumours, RNA levels were elevated for: (1) TGFB1, whose product TGF-Beta is secreted by tumour associated M2-type macrophages, as noted in gliomas, where it promotes stemness and migration [40].