In accordance, blocking Tlr7 (Fig. 1f) and Tlr9 (Fig. 1g) signalling significantly reduced IL-6 in both wt and Ifitm3−/− cells to similar levels following infection with MCMV, suggesting that Ifitm3-mediated regulation of these responses restricts MCMV-induced cytokine production. The gene discussed is TLR7; the disease is infection.