Our observations suggested colocalization (yellow) between TLR2 and Nogo-B after HCMV exposure (Fig. 7a and Supplementary Fig. 5); and that TLR2 and Nogo-B cellular localisation was influenced by IFITM3, with more TLR2/Nogo-B localisation visible as cytoplasmic puncta in IFITM3−/− iPS-DCs 24 h post infection (Fig. 7a). The gene discussed is RTN4; the disease is infection.