Sitia et al. investigated the effect of low‐dose dual APT (aspirin + clopidogrel) in an HBV‐positive transgenic mice model, observing a reduction of the intrahepatic HBV‐specific CD8+ T‐cells, a decrease in the severity of liver fibrosis and a reduced incidence of HCC.8, 37, 38. This evidence concerns the gene CD8A and hepatocellular carcinoma.