This approach was taken by Translate Bio who recently reported on their first-in-man Phase I/II trial of repeat delivery of MRT5005, a formulation of fully functional CFTR mRNA with lipid nanoparticles https://www.biospace.com/article/releases/translate-bio-presents-mrt5005-data-at-the-33rd-annual-north-american-cystic-fibrosis-conference/. Here, CFTR is linked to cystic fibrosis.