In contrast, mutations in the gene CEP290, which a cilia protein expressed in PRs and other ciliated cells, can cause a wide range of diseases, including nonsyndromic LCA10 as well as Bardet–Biedl syndrome,18 Joubert syndrome,19 Senior–Loken syndrome,20 and Meckel–Gruber syndrome.21 This evidence concerns the gene CEP290 and Joubert syndrome.