In this study, we show that Parkinson’s disease GWAS risk gene candidates KAT8 (lysine acetyltransferase 8) and KANSL1 (KAT8 Regulatory NSL Complex Subunit 1), which are both part of the non-specific lethal (NSL) complex, are new and important regulators of PINK1-mediated mitochondrial quality control. The gene discussed is KANSL1; the disease is Parkinson disease.