To screen for Parkinson’s disease GWAS candidate genes that play a role in PINK1-mitophagy, and thus are likely to be genuine risk genes for Parkinson’s disease, we have set up and optimized a high-content screening for pUb(Ser65), a marker of PINK1-dependent mitophagy initiation, a key pathway in Parkinson’s disease pathogenesis. This evidence concerns the gene PINK1 and Parkinson disease.