KANSL1 and Parkinson disease: KANSL1 is located within the extensively studied inversion polymorphism on chromosome 17q21 (Supplementary Fig. 13A and B), which also contains MAPT—a gene frequently postulated to drive Parkinson’s disease risk at this locus.53 While the majority of individuals inherit this region in the direct orientation, up to 25% of individuals of European descent have a ∼1 Mb sequence in the opposite orientation,54,55 inducing a larger ∼1.3–1.6 Mb region of LD.