Notably, KAT8 was selected as a candidate gene on the basis of all three prioritization criteria: namely, proximity of the lead SNP to an ORF (Fig. 1D), colocalization of a brain-derived eQTL signal with a Parkinson’s disease GWAS association signal (Supplementary Fig. 3) and evidence of protein–protein interaction with a known Parkinson’s disease gene (Table 1). This evidence concerns the gene KAT8 and Parkinson disease.