Histopathological changes of TMA have been described in number of glomerular diseases without concurrent MAHA or thrombocytopenia, for example, IgA, ANCA associated vasculitis, membranous nephropathy, focal segmental glomerulosclerosis and C3 glomerulopathy (C3G)/mesangioproliferative glomerulonephritis (MPGN).52, 65, 93. The gene discussed is CD79A; the disease is complement 3 glomerulopathy.