Therefore, the purpose of this study is to examine the performance of plasma biomarkers, including Aβ42, Aβ40, Aβ42/Aβ40 ratio, p‐tau181, NfL, and T‐tau in Obj‐SCD relative to NC cross‐sectionally and whether baseline plasma biomarkers affect brain Aβ, cognition domains, and image indicators. The gene discussed is NEFL; the disease is Schnyder corneal dystrophy.