Consistent with skin tumor immunity, cytotoxic T lymphocyte (CD8+HLA-DR+) frequency was greater in BCC (36.23% ± 6.22% [n = 8]) than that in SCC (20.16% ± 1.70% [P < 0.01, n = 14]) and normal skin (20.14% ± 2.17% [P < 0.05, n = 7]). This evidence concerns the gene CD8A and skin neoplasm.