SPON2 and skin basal cell carcinoma: In keeping with the prominent stroma around BCC, a volcano plot (fold change > 2.0 or < –2.0, adjusted P < 0.01) identified 16 of the 24 overexpressed genes in BCC compared with normal skin that were associated with extracellular matrix remodeling: collagen genes (COL1A1, -1A2, -1A2, -3A1, -5A1, -5A2, and -6A3), proteoglycans and glycoproteins (VCAN, FBN3, TNC, CSPG4, and LUM), other extracellular proteins (SPON2 and CALD1), and proteases (MMP11) (Supplemental Table 1).