In keeping with the prominent stroma around BCC, a volcano plot (fold change > 2.0 or < –2.0, adjusted P < 0.01) identified 16 of the 24 overexpressed genes in BCC compared with normal skin that were associated with extracellular matrix remodeling: collagen genes (COL1A1, -1A2, -1A2, -3A1, -5A1, -5A2, and -6A3), proteoglycans and glycoproteins (VCAN, FBN3, TNC, CSPG4, and LUM), other extracellular proteins (SPON2 and CALD1), and proteases (MMP11) (Supplemental Table 1). This evidence concerns the gene TNC and skin basal cell carcinoma.