TP53 and lung adenocarcinoma: For example, TP53 inactivation in lung adenocarcinomas was found to activate progestin and adipoQ receptor 11 (PAQR11)-mediated prometastatic secretory vesicle biogenesis in the Golgi, resulting in the autocrine activation of a PLAU receptor/STAT3/PAQR11 feedforward signaling loop that triggers an immunosuppressive TME rich in effector/memory CD8+ T cells and M1 macrophages (Tan et al., 2021a).