Moreover, patients with both high TMB and PD-L1 expression in more than 50% of the tumor cells had a higher response rate (75%) compared to patients with only one of these factors (32% among patients with a high tumor-mutation burden only and 34% among those with a PD-L1 expression level of ≥50% only; Carbone et al., 2016). This evidence concerns the gene CD274 and neoplasm.