NFKB1 and cancer: As NF-κB-binding sites are found in the enhancers and promoters of numerous immunoregulatory genes (Natoli et al., 2005), it is not surprising that NF-κB plays a pivotal role in cancer by fueling a pro-tumorigenic inflammatory environment through the induction of classical NF-κB target genes (Baud and Karin, 2009; DiDonato et al., 2012).