KRAS and neoplasm: Chemotherapy-resistant KRAS patients have a large population of pro-tumor M2-macrophages that support the formation of the immunosuppressive TME phenotype (Katopodi et al., 2021), whereas the re-programming of M2-protumor macrophages through modulation of the Wnt/β-catenin pathway reduced primary and metastatic lung tumors (Sarode et al., 2020).