EGFR and non-small cell lung carcinoma: Regarding EGFR mutation, The ADAURA study, a randomized, double-blind clinical phase 3 trial, showed that adjuvant therapy with osimertinib, a third-generation EGFR-tyrosine kinase inhibitors (TKI), significantly improved the disease-free survival among patients with stage IB to IIIA EGFR mutation–positive NSCLC (Wu et al., 2020).