IL-6, CXCL8 and multiple other chemokines (e.g. CXCL1, 2, 3, 5, CCL20, CCL2) are under complex control of ‘master cytokines’ such as IL-1α or IL-1β, which can induce the transcriptional and post-transcriptional expression of all of these factors simultaneously through a network of signaling pathways and transcription factors (including the NF-κB system) in multiple normal as well as cancer cells from both mice or humans (Gaestel et al., 2009; Jurida et al., 2015; Weber et al., 2010; Wolter et al., 2008; Ziesché et al., 2013). Here, IL6 is linked to cancer.