ACE2 and COVID-19: Most COVID-19–associated olfactory dysfunctions are transient, lasting approximately 2 to 3 weeks.22,27 This finding is consistent with the fact that SARS-CoV-2 has a high affinity for the sustentacular cells of the olfactory epithelium that express angiotensin-converting enzyme 2 (ACE2) and possess substantial capacity for repair and regeneration after damage.28,29,30,31,32 However, epithelial injury secondary to ACE2-mediated entry does not completely explain the inverse association between olfactory dysfunction and disease severity.