Thus, while TNBC constitutes about 15% of all US breast cancers, the percentage of TNBC in WHI is 7%.37 Moreover, the prevalence of tumor BRCA1 methylation is higher in younger compared with older women with TNBC.4 Thus, in our previous study assessing BRCA1 WBC methylation status in women at all ages who already received a diagnosis of HGSOC19 the odds ratio associated with HGSOC varied between 2.2 to 2.9 and was higher among younger compared with older individuals. This evidence concerns the gene BRCA1 and breast carcinoma.