Notably, BRCA1 promoter methylation and BRCA1 germline pathogenic variants have been reported to be mutually exclusive in breast cancer tissue4 as well as in WBC collected from patients with a diagnosis of HGSOC.19 The present study was not powered to assess different racial and ethnic groups, precluding conclusions for risk in African American individuals, for whom the incidence of TNBC is known to be elevated. This evidence concerns the gene BRCA1 and breast cancer.