Some researchers found that samples with lymph node metastasis have lower E-cadherin expression.40 Some scholars have confirmed that E-cadherin is a promising biomarker of TSCC.41 Therefore, H19/miR-675-5p/CDH1 is a key signaling pathway in the migration and invasion of tongue cancer cells. The gene discussed is CDH1; the disease is metastatic malignant neoplasm in the lymph nodes.