PTPN11 and obesity due to melanocortin 4 receptor deficiency: Moreover, inhibition of SHP2, PDHA1, or ROS decreased the secretion of the pro-inflammation cytokine, IL-6 (Fig. 6A), a key mediator of obesity-mediated PDAC hallmarks (Park et al. 2010; Nagathihalli et al. 2016; Razidlo et al. 2018; Thomas 2019).