While SHP2 has been implicated in adipocyte maturation (Uehara et al. 2007; Bae et al. 2012; He et al. 2013) and pancreatic cancer development (Ruess et al. 2018), the roles of SHP2 in adipocyte maintenance and adipocyte-cancer cell interaction has not been explored. Here, PTPN11 is linked to cancer.