The main pathological feature of DN is glomerular sclerosis, which is manifested by the hypertrophy of glomerular mesangial cells, and overexpression of ECM, including collagen, fibronectin and laminin; these proteins are secreted outside the mesangial cells and deposited in the glomerulus, leading to glomerular sclerosis, which eventually develops into renal fibrosis (Hua et al. The gene discussed is FN1; the disease is liver dysplastic nodule.