PTEN and adenocarcinoma: Female Pten+/− mice also have a very high incidence of endometrial lesions, with almost 100% of the mice showing atypical endometrial hyperplasia by the age of 6 months, a phenotype also observed in all mice on the eRapa diet (adenocarcinoma was found only in one mouse on the control diet) (Figures 1F and 3A; Table 1).