PTEN and pheochromocytoma: Although there are no known links between PTEN and the pathogenesis of adrenal phaeochromocytomas in humans, Pten+/− mice present with a high incidence of phaeochromocytomas [21, 30], which was significantly reduced in both female and male mice on the eRapa diet (Figures 1F,G and 2D; Table 1).