The data presented here on cancer prevention by a low dose of rapamycin in a model of PHTS support the use of rapamycin, and possibly other PI3K pathway inhibitors, in a broader setting of cancer prevention, potentially as part of a so‐called ‘poly‐pill’ approach that has been shown to effectively reduce the burden of cardiovascular disease in humans [60, 61]. Here, PIK3CA is linked to PTEN hamartoma tumor syndrome.