Type III IFNs, the early-responding cytokines in epithelial cells, were detected early in B.6 and B.1.1.8 infections and later in Alpha infection (IFNL1, IFNL2, and IFNL3) at 48 hpi, thereby indicating that the late surge of TR in Alpha infection could partly be triggered by this class of IFNs (IFNL2 and IFNL3 in Fig. 6B; IFNL1 in Fig. S6). Here, IFNL3 is linked to infection.