Disrupted endothelial integrity might cause neurodegenerative disease, including vascular dementia and AD.[6] In patients with diabetes, hyperphosphorylation and aggregation of Tau proteins along with amyloid ß (Aß) plaques are observed,[2b] which are the most common pathological hallmarks of neurodegeneration.[2, 7] Although changes in endothelium and neurons along with hyperglycemia have been observed, however, the link between neuro‐vasculature remains debatable. This evidence concerns the gene MAPT and Alzheimer disease.