Given the ability of TBT to activate some nuclear receptors, such as retinoid X receptors (RXRs) and PPARγ that are involved in adipogenesis (Nakanishi, 2008), it was expected that TBT may increase the incidence of obesity (Grun, 2014; Grun & Blumberg, 2006) and it is, thus, currently considered as a potent inducer of adipogenesis in vertebrates. This evidence concerns the gene PPARG and obesity due to melanocortin 4 receptor deficiency.