PUM2 and temporal lobe epilepsy: Specifically, (1) Pum1 or Pum2 haploinsufficiency is associated with spontaneous seizures in mice (Follwaczny et al., 2017; Gennarino et al., 2015; Siemen et al., 2011), (2) PUM2 expression is reduced in human patients suffering temporal lobe epilepsy and in rat hippocampus following pilocarpine-induced seizure (Wu et al., 2015), and (3) pum expression is reduced in Drosophila genetic seizure mutations (Lin et al., 2017).