DNMT3A and acute myeloid leukemia: To model how the combination of these human AML mutations manifests when present in various combinations, we bred mice to obtain 8 distinct genotypes: WT, single heterozygous for Tet2+/–, Flt3ITD/WT, and Dnmt3a+/–; double heterozygous for Tet2+/– Dnmt3a+/– (TD), Tet2+/– Flt3ITD/WT(TF), and Dnmt3a+/– Flt3ITD/WT (DF); and triple heterozygous for Tet2+/– Flt3ITD/WT Dnmt3a+/– (TFD).