Recently, triple-mutants of NPM1–FLT3-ITD–IDH1/2 (38), WT1–FLT3-ITD–NUP98-NSD1 (39) fusion, and DNMT3A–NPM1–FLT3-ITD (40) have been reported in patients with AML with poor overall survival. This evidence concerns the gene DNMT3A and acute myeloid leukemia.