Remarkably, the genes identified in the TFD AML HSC/Ps from the human TCGA data sets showed a significant overlap with the genes differentially expressed in the TFD HSC/Ps derived from the mutant mice versus in mice with no mutations in Tet2, Flt3, and Dnmt3a (P = 0.08 and 0.00016 for up- and downregulated genes, respectively); this suggests remarkable evolutionary conservation in the gene expression profile between mice and human AML bearing a combination of TFD mutations. This evidence concerns the gene DNMT3A and acute myeloid leukemia.