Consistent with independence from Type 2 cytokines, in normal mice following infection, we did not observe significantly increased levels of Il4, Il5, or Il13, at timepoints when tuft cells are present in the lung – 12, 21, or 51 days post infection, although we did observe significant induction of Type 2 cytokines at earlier timepoints (Figure 3—figure supplement 5A). This evidence concerns the gene IL4 and infection.