Notably, mRNA expression and phosphoproteomic changes in VHIPP of old Pde11a WT vs KO mice were enriched for pathways related to Alzheimer's disease, axon guidance, regulation of transport, chemical synaptic transmission, as well as the axon, synapse, presynapse, and synaptic vesicle (Table 2). Here, PDE11A is linked to early-onset autosomal dominant Alzheimer disease.