RNA sequencing and phosphoproteomics analysis of the VHIPP from old Pde11a KO versus WT mice suggest PDE11A4 overexpression contributes to ARCD of social memories primarily via the cGMP‐PKG pathway as opposed to the cAMP‐PKA pathway and confirm downstream effects on multiple pathways associated with ARCD and Alzheimer's disease (Table 2). This evidence concerns the gene PDE11A and early-onset autosomal dominant Alzheimer disease.