Invasive hemodynamics under these conditions revealed a significant difference in LV developed pressure between the saline and insulin groups at the end of euglycemic hyperinsulinemia (Figure 5, LV developed pressure—saline vs. insulin: 88.7 ± 0.1 vs. 79.4 ± 2.4, p < 0.05 by t‐test). This evidence concerns the gene INS and Hyperinsulinemia.