The signaling pathways that regulate lipid metabolism in endometrial cancer include MAPK, JAK/STAT, NF-kB/Notch1, ERRα involved in lipid metabolism reprogramming, and other molecules including ATP citrate lyase (ACLY), monoacylglycerol lipase (MAGL), choline kinase alpha (CHKA), cyclin-dependent kinase 8 (CDK8), and so on. The gene discussed is CDK8; the disease is endometrial cancer.