Associated risk factors include continued estrogen exposure (ovarian anovulatory dysfunction and estrogen-secreting ovarian tumors (estrogen replacement therapy without progesterone protection and selective estrogen receptor modulator therapy, such as tamoxifen)), metabolic abnormalities (such as obesity and diabetes), early menarche, infertility, delayed menopause, carrying genetic susceptibility genes for endometrial cancer, such as Lynch syndrome, Cowden syndrome, and polymerase proofreading-associated polyposis (PPAP), and advanced age [4, 5]. The gene discussed is ESR1; the disease is endometrial cancer.