Also, a highly suppressive subset of the CD4+ Foxp3– T cell population was described in CRC patients to express multiple immune checkpoints (such as LAG-3, PD-1, and CTLA-4) and produce immunosuppressive cytokines such as IL-10 and transforming growth factor (TGF)-β (70). This evidence concerns the gene CTLA4 and colorectal carcinoma.