NLRP3 and adult-onset Still disease: Chen et al. found that NLR family pyrin domain containing 3 (NLRP3)-inflammasome signaling was strongly associated with AOSD; they studied single-nucleotide polymorphisms (SNPs) involved in NLRP3-inflammasome signaling and reported that SNP rs11672725 of the CARD8 gene was significantly associated with AOSD susceptibility.