ATG16L1 and Skin rash: Hung, Chen and Lan et al. reported another update last year showing that SNPs of autophagy-related 16-like 1 (ATG16L1) gene have associations with the AOSD clinical phenotype in particular, and the AA/CC/TT haplotype of this gene might be linked to the systemic pattern of manifestation and specific clinical features of AOSD, that is, skin rash (31).