Some experts believe that IFN-γ functions by inducing overexpression of cytokines or chemokines like IL-18 and CXCL-10 in the inflammatory pathogenesis of AOSD; moreover, these induced cytokines directly correlate to disease activity, so they can be used as biomarkers of disease activity and treatment efficacy (102–104). This evidence concerns the gene IL18 and adult-onset Still disease.