Another study found that SNP rs11102024, which is 5′ upstream of colony-stimulating factor 1 (CSF1), was associated with AOSD; this gene encoding macrophage-CSF (M-CSF) and the rs11102024 T allele were related to higher M-CSF levels and a systemic rather than chronic articular manifestation of AOSD (29). The gene discussed is CSF1; the disease is adult-onset Still disease.