PCT (OR = 2.23, 95% CI: 1.55–3.19; p < 0.001), CRP (OR 1.62, 95% CI 1.08–2.44; p = 0.020), and qSOFA (OR 1.48, 95% CI 1.03–1.98; p < 0.001) were found to be the independent predictors of culture-proven bacterial infection, but presepsin was not. Here, CRP is linked to bacterial infectious disease.