CXCL16 and neoplasm: Some reports have indicated that CXCR3 and its corresponding ligands, CXCL14 and CXCL16, recruit primary immune cells with immune regulatory functions and pro-tumor activities, such as tumor-associated macrophages (TAMs) and neutrophils (TANs), myeloid-derived suppressor cells (MDSCs), and Treg cells (120–122).