THBS1 and stroke disorder: Therefore, we analysed Thbs1 expression in such a model, in which photothrombotic stroke is produced by systemic administration of a photosensitizer followed by targeted irradiation of the primary motor cortex (Fig. 1D).4 RNAscope in situ hybridization showed that the number of Thbs1-positive astrocytes in the peri-infarct scar area was 6-fold upregulated 14 days after stroke compared with sham (Fig. 1E and F).