FTO and obesity due to melanocortin 4 receptor deficiency: We hypothesized that individuals carrying the obesity predisposing A allele would exhibit lower resting CBF in the frontal lobe, a region shown to be sensitive to both obesity and genetic variation in FTO (Ho et al., 2010b; Alosco et al., 2012; Olivo et al., 2016; Vainik et al., 2018), compared to T homozygotes.