Since our study was in a relatively young sample we do not know whether these differences in rCBF will likely translate to more accelerated cognitive losses with increasing age, but most evidence suggests that FTO is not a common polymorphism associated with accelerated cognitive decline with only a single study linking the polymorphism to verbal fluency in elderly men with overweight and obesity (Benedict et al., 2011). The gene discussed is FTO; the disease is obesity due to melanocortin 4 receptor deficiency.