Although slightly different, all definitions include patients with previous heart disease and abnormal left ventricular function, elevated cardiac biomarkers before initiation of anticancer therapy, prior mediastinal radiotherapy, and patients with prior or ongoing anthracycline treatment or HER2 (Human Epidermal Growth Factor Receptor-2) targeted agents such as trastuzumab and trastuzumab-derived antibody-drug conjugates (58). This evidence concerns the gene ERBB2 and heart disorder.