Activation of IRF3 and NF-κB can upregulate the levels of IFNs, interferon stimulated genes (ISGs), and inflammatory factors, however, in a large number of conditions, excessive inflammation causes damage to host tissue and leading to organ dysfunction, which in turn regulate the progression of multiple autoimmune diseases, metabolic disorders, neurodegenerative diseases, and cardiovascular diseases, collectively termed as sterile inflammatory diseases (10–13). The gene discussed is STING1; the disease is cardiovascular disorder.