Epithelial-to-mesenchymal transition is a crucial process for cancer metastasis, in which epithelial cells obtained the phenotype of mesenchymal cells including decreased expression of adhesion molecular, such as E-cadherin (E-cad), on cell membrane, obtained vimentin (VIM)–rich intermediate filaments networks, and switched to the mesenchymal cells’ morphology (21, 22). This evidence concerns the gene CDH1 and cancer.